Second Trimester Quadruple Marker
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Second Trimester Quadruple Marker
The second trimester quadruple marker test, also known as the quadruple screen or quad screen, is a prenatal screening test performed between 15 and 20 weeks of pregnancy. It measures four biomarkers in the mother’s blood: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), estriol, and inhibin-A. This test assesses the risk of certain fetal conditions, including Down syndrome, trisomy 18, and neural tube defects. While it is a useful screening tool, it is not diagnostic and has a moderate sensitivity of approximately 80% for Down syndrome, meaning it can help identify those at higher risk but may miss some cases.
When is the Second Trimester Quadruple Marker Test Performed?
- Typically between 15 and 20 weeks of pregnancy.
How Does the Test Work?
Blood Sample: A blood sample is taken from the mother.
Measurement: The levels of the four markers are measured in the blood.
Risk Assessment: The results are analyzed to determine the risk of chromosomal abnormalities, such as Down syndrome, trisomy 18, and neural tube defects.
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