Double Marker
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Double Marker
The double marker test is a prenatal screening done between the 9th and 13th weeks of pregnancy to assess the risk of chromosomal abnormalities like Down syndrome and trisomy 18. It measures levels of two markers in the mother’s blood: PAPP-A and hCG. With a sensitivity of about 60-70% for detecting Down syndrome, it helps identify pregnancies at higher risk, prompting further diagnostic testing if needed.
How Does the Double Marker Test Work?
- Blood Sample: A blood sample is taken from the mother.
- Measurement: The levels of beta-HCG and PAPP-A are measured in the blood.
- Risk Assessment: The results are analyzed to determine the risk of chromosomal abnormalities, such as Down syndrome or trisomy 18.
When is the Double Marker Test Performed?
- Typically between 10 and 13 weeks of pregnancy.
Note: The double marker test is a screening test, not a diagnostic test. A positive result does not guarantee a diagnosis of a chromosomal abnormality. If the results suggest an increased risk, further diagnostic tests, such as amniocentesis or chorionic villus sampling, may be recommended.
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